Together with the solubility, the p

Together with the solubility, the permeability behaviour
should also be considered in the development of formulation for
oral administration. Drug absorption from solid dosage forms after
oral administration depends on the release of the drug substance
from the drug product, the dissolution or solubilization of the drug
under physiological conditions, and the permeability across the
gastrointestinal tract. Because of the critical nature of the first two
steps, in vitro dissolution may be relevant to the prediction of in
vivo performance.