Scientific research focuses on the missing elements, such as social networks interoperability, cloud interoperability, and ecosystems interoperability. Thus, an E-business Interoperability Framework should address all interoperability issues. Moreover, metrics and properties could be identified to improve the development of interoperability between systems. Major challenges lie ahead in the scientific area of software systems interoperability in view of new technological and com- puter science’s advances that indicate the need of a ubiquitous approach that guarantees a high degree of maintainability against the rapid software technology evolution.