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Magnetic coreeshell Fe3O4@SiO2 nanoparticles as special immobilizing carrier of biomolecules have aroused great interest in current researches because they are biocompatible, easily renewable, and are stable against degradation . The inner iron-oxide core with outer shell of silica not only stabilizes the nanoparticles in solution but also provides sites for surface modificationwith various biomedical ligands in biomedical applications
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