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Variable Moderate-to-Severe Disease Mild DiseaseQIV GroupControl GroupRelative Risk with QIV (95% CI)QIV GroupControl GroupRelative Risk with QIV (95% CI)Clinical characteristicsNo. of rt-PCR–confirmed cases 14 52Temperature > 39°C with no other defining symptom (no. of patients)12 41 0.29 (0.16–0.56)Acute otitis media with no other defining symptom (no. of patients) 0 1 —Lower respiratory tract illness (no. of patients) † 2 10 0.20 (0.04–0.92)With pneumonia‡ 0 3 —Without pneumonia 2 7 0.29 (0.06–1.3 8)Effect on daily activities and utilization of health care resourcesNo. of rt-PCR–confirmed cases§ 14 52 45 76Absence from schoolNo. of children affected 8 35 0.23 (0.11–0.49) ¶ 23 41 0.56 (0.34–0.94) ¶No. of school days missed per illness 4.1±3.1 5.0±3.7 — 3.6±2.5 3.4±1.9 —Parental absence from work to take care of the childNo. of parents affected 7 18 0.39 (0.16–0.93) ¶ 18 18 1.01 (0.52–1.93) ¶No. of work days missed per illness 3.1±2.0 4.2±3.4 — 2.5±1.6 4.8±4.6 —Visit to doctor or other medical personNo. of children affected 14 45 0.31 (0.17–0.57) 35 65 0.54 (0.36–0.81)No. of doctor visits per illness 2.3±1.8 1.8±1.7 — 1.4±1.1 1.4±1.0 —HospitalizationNo. of children affected 11 4 0.25 (0.03–2.25) 0 1 —No. of days in hospital per illness 5.0 4.8±2.9 — — 4.0
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