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The lipid-rich clogged follicle is an ideal substrate for P. acnes which secretes several extracellular products that may be significant in the etiology of acne including lipases, hyaluronidase, proteases, chemotactic factors for neutrophils, lymphocytes, and macrophagesIn the pathogenesis of acne, the skin microbiota especially Propionibacterium acnes plays a notable role
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