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Rituximab is a chimeric monoclonal antibody that targets the CD20 B-cell antigen.•This antigen is expressed on 90% of B-cell neoplasms•The precise biological functions of CD20 are uncertain, but the antibody is believed to function by flagging the B-cells for destruction by the body’s own immune system, including ADCC, CDC, and apoptosis.•This antibody thus leads to the elimination of all B-cells from the body (including cancerous ones), allowing new, healthy B-cells to be produced from lymphoid stem cells.
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