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Breadfruit (Artocarpus altilis) derived from a. camansi Blanco and a. Mariannensis Trecul around 3000 years ago. The purpose of this research is to unearth potential plants that have activity as a traditional medicine to add to the community's wishes back using traditional medicine as a treatment alternative. Anti diabetic test extracts of dried leaves of white rats, methods of breadfruit test One Way Anova showed p:0.000 (p < 0.05) or Ha received, and Post Hoc Tests showed extracts give the effect on glucose levels. Testing of antioxidant activity through the parameter value of the AA (the value of antioxidant activity%), total phenolic levels, and the levels of flavonoids extracts of breadfruit leaves. Using the method of Carotene Bleaching, results showed ME and RE have the highest antioxidant activity of 75.4% 77,4%, and the rate of RE (reflux ethanol) has antioxidant activity. Water extract of Nefroprotektif assay activity leaves breadfruit against GgGA rat strain wistra males, creatinin Levels tested method of Kinetic colorimetric assay.
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