BACKGROUND—Contact lens induced pap

BACKGROUND—Contact lens induced papillary conjunctivitis (CLPC) continues to be a major cause of dropout during contact lens extended wear. This retrospective study explores risk factors for the development of CLPC during silicone hydrogel lens extended wear.
METHODS—Data from 205 subjects enrolled in the Longitudinal Analysis of Silicone Hydrogel Contact Lens (LASH) study wearing lotrafilcon A silicone hydrogel lenses for up to 30 days of continuous wear were used to determine risk factors for CLPC in this secondary analysis of the main cohort. The main covariates of interest included substantial lens-associated bacterial bioburden, and topographically determined lens base curve-to-cornea fitting relationships.
Additional covariates of interest included history of prior adverse events, time of year, race, education level, gender and other subject demographics. Statistical analyses included univariate logistic regression to assess the impact of potential risk factors on the binary CLPC outcome, and Cox proportional hazards regression to describe the impact of those factors on time-to-CLPC
diagnosis.
RESULTS—Across 12 months of follow-up, 52 subjects (25%) experienced CLPC. No associations were found between CLPC development and the presence of bacterial bioburden,lens-to-cornea fitting relationships, history of prior adverse events, gender or race. CLPC development followed the same seasonal trends as the local peaks in environmental allergans.
CONCLUSIONS—Lens fit and biodeposits, in the form of lens associated bacterial bioburden, were not associated with the development of CLPC during extended wear with lotrafilcon A silicone hydrogel lenses.

Results (Indonesian) 2:

Lensa Kontak LATAR BELAKANG-diinduksi konjungtivitis papiler (CLPC) terus menjadi penyebab utama putus sekolah selama lensa kontak diperpanjang memakai. Penelitian retrospektif ini mengeksplorasi faktor risiko untuk pengembangan CLPC selama lensa silikon hidrogel diperpanjang pakai.
METODE-data dari 205 subyek yang terdaftar dalam Analisis Longitudinal Silicone Hydrogel Lensa Kontak (Lash) studi mengenakan lotrafilcon A lensa silikon hidrogel sampai 30 hari pakai terus menerus digunakan untuk menentukan faktor risiko CLPC dalam analisis sekunder ini dari kelompok utama. Kovariat utama kepentingan termasuk lensa-terkait beban biologis bakteri substansial, dan basis lensa kurva-to-kornea hubungan pas topografi ditentukan.
kovariat menarik termasuk sejarah efek samping sebelumnya, waktu tahun, ras, tingkat pendidikan, jenis kelamin dan subjek lainnya demografi. Analisis statistik termasuk regresi logistik univariat untuk menilai dampak dari faktor-faktor risiko potensial pada hasil biner CLPC, dan Cox bahaya proporsional regresi untuk menggambarkan dampak dari faktor-faktor tersebut di waktu-ke-CLPC
diagnosis.
HASIL-Di 12 bulan masa tindak lanjut, 52 subyek (25%) mengalami CLPC. Tidak ada hubungan yang ditemukan antara pengembangan CLPC dan adanya beban biologis bakteri, hubungan pas lensa-to-kornea, sejarah efek samping sebelumnya, jenis kelamin atau ras. Pengembangan CLPC mengikuti tren musiman sama dengan puncak lokal di allergans lingkungan.
KESIMPULAN-Lens fit dan biodeposits, dalam bentuk lensa terkait bioburden bakteri, yang tidak terkait dengan perkembangan CLPC selama memakai diperpanjang dengan lotrafilcon A lensa silikon hidrogel.