Lifetime Alcohol Use Disorder in Offspring
Table 2 summarizes prevalence, unadjusted ORs, AORs, and 95% CIs of AUD in the 3 offspring groups. Prevalence of lifetime AUD in offspring gradually increased from 23.1% in offspring of non-AUD parents to 40.4% in offspring of 1 AUD parent and 54.3% in offspring of 2 AUD parents. Compared to offspring of non-AUD parents, offspring of 1 AUD parent had 2.51-fold increased odds of lifetime AUD (AOR = 2.51). Offspring of 2 AUD parents had 4.44-fold increased odds of lifetime AUD (AOR = 4.44) compared with offspring of non-AUD parents. In addition, tetrachoric correlations showed a significant positive relationship between number of AUD parents and AUD in offspring of 1 AUD parent (r = 0.278, P < .001) and in offspring of 2 AUD parents (r = 0.368, P < .001).