The megakaryocyte is the central ce

The megakaryocyte is the central cell in thrombopoiesis, the intricately regulated series of events by which platelets are generated. Megakaryocytes are unique, polyploid
hematopoietic cells that are found only in mammals and are specialized to produce and
release platelets and immediate platelet precursors into the circulation (reviewed in
Reference 24). The global process of thrombopoiesis includes megakaryocyte precursor
development from stem cells and cell fate determination; the remarkable events of endomitosis and the development of polyploidy; internal membrane, tubular, cytoskeletal,
and granule evolution directed by key transcription factors and transcriptional programs; regulated apoptosis; and additional intricate and time-dependent events (24). Cytokines regulate megakaryocyte development and platelet formation at multiple steps.
Megakaryopoiesis is driven by thrombopoietin (TPO), although TPO and other cytokines
critical for megakaryocyte development are not required for the late stages of
thrombopoiesis in vitro

Results (Indonesian) 1:

Megakaryocyte adalah sel pusat di thrombopoiesis, rumit diatur rangkaian peristiwa yang dihasilkan trombosit. Megakaryocytes unik, polyploidsel-sel hematopoietik yang ditemukan hanya di mamalia dan khusus untuk menghasilkan danrilis trombosit dan segera trombosit prekursor ke dalam sirkulasi (dibahas dalamReferensi 24). Proses global thrombopoiesis termasuk megakaryocyte pendahulupengembangan dari stem cells dan penentuan nasib sel; peristiwa-peristiwa luar biasa endomitosis dan pengembangan polyploidy; membran internal, tabung, cytoskeletal,dan evolusi granul disutradarai oleh faktor-faktor transkripsi kunci dan transcriptional program; diatur apoptosis; dan acara rumit dan bergantung pada waktu tambahan (24). Sitokin mengatur megakaryocyte pengembangan dan trombosit pembentukan di beberapa langkah.Megakaryopoiesis didorong oleh thrombopoietin (TPO), meskipun TPO dan sitokin lainnyapenting untuk pengembangan megakaryocyte tidak diperlukan untuk tahap akhirthrombopoiesis secara in vitro