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Together with the solubility, the permeability behaviourshould also be considered in the development of formulation fororal administration. Drug absorption from solid dosage forms afteroral administration depends on the release of the drug substancefrom the drug product, the dissolution or solubilization of the drugunder physiological conditions, and the permeability across thegastrointestinal tract. Because of the critical nature of the first twosteps, in vitro dissolution may be relevant to the prediction of invivo performance.
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