synthetic steroid that antagonizes

synthetic steroid that antagonizes aldosterone at intracellular cytoplasmic receptor sites.
The spironolactone-receptor complex is inactive  prevents translocation of the receptor complex into the nucleus of the target cellcannot bind to DNA  failure to produce proteins that are normally synthesized in response to aldosterone.
normally stimulate the Na+/K+-exchange sites of the collecting tubule.
A lack of mediator proteins prevents Na+ reabsorption and, therefore, K+ and H+ secretion.
Contoh: spironolactone & eplerenone

Results (Indonesian) 2:

steroid sintetis yang antagonis aldosteron pada reseptor sitoplasma intraseluler.
Kompleks spironolactone-reseptor tidak aktif  mencegah translokasi kompleks reseptor ke inti dari target cellcannot mengikat DNA  gagal untuk menghasilkan protein yang biasanya disintesis dalam menanggapi aldosteron .
biasanya merangsang Na + / K + -exchange situs tubulus pengumpul.
kurangnya protein mediator mencegah reabsorpsi Na + dan, karena itu, K + dan H + sekresi.
Contoh: spironolactone & eplerenon