Peak Plasma Time: 10-60 min (PO imm

Peak Plasma Time: 10-60 min (PO immediate-release); 60-120 min (PO extended-release); 6 hr (PO 500 mg, conventional tablet); 8 hr (PO 650 mg, extended-release tablet)

Peak Plasma Concentration: 2.1 mcg/mL (PO 500 mg, conventional tablet); 1.8 mcg/mL (PO 650 mg, extended-release tablet)

Onset: 1 hr

Distribution: 1 L/kg

Protein Bound: 10 to 25%

Metabolism: Liver (microsomal enzyme systems); conjugation (glucuronic/sulfuric acid)

Metabolites: N-acetyl-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI; further metabolized via conjugation with glutathione

Half-life elimination: 1.25-3 hr (adolescents); 2-5 hr (children); 4 hr (infants); 7 hr (neonates); 2-3 hr (adults)

Excretion: urine (principally as acetaminophen glucuronide with acetaminophen sulfate/mercaptate)

Results (Indonesian) 1:

Puncak Plasma waktu: 10-60 menit (PO segera-rilis); 60-120 menit (PO diperpanjang-release); 6 jam (PO 500 mg, konvensional tablet); 8 jam (PO 650 mg, diperpanjang rilis tablet)Kadar Plasma puncak: 2.1 mcg/mL (PO 500 mg, konvensional tablet); 1.8 mcg/mL (PO 650 mg, diperpanjang rilis tablet)Onset: 1 hrDistribusi: 1 L/kgTerikat protein: 10 sampai 25%Metabolisme: Hati (sistem enzim microsomal); konjugasi (asam glukuronat dan sulfat)Metabolit: N-asetil-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI; Selanjutnya dimetabolisme melalui konjugasi dengan glutathionePenghapusan paruh: 1,25-3 hr (remaja); 2-5 jam (anak); 4 hr (bayi); 7 jam (neonatus); 2-3 jam (dewasa)Ekskresi: urin (terutama sebagai asetaminofen glukuronida dengan asetaminofen sulfat/mercaptate)

Results (Indonesian) 2:

Puncak Plasma Waktu: 10-60 menit (PO segera-release); 60-120 menit (PO diperpanjang-release); 6 jam (PO 500 mg, tablet konvensional); 8 jam (PO 650 mg, extended-release tablet)

Puncak Plasma Konsentrasi: 2.1 mcg / mL (PO 500 mg, tablet konvensional); 1,8 mcg / mL (PO 650 mg, diperpanjang-release tablet)

Onset: 1 jam

Distribusi: 1 L / kg

Protein Bound: 10 sampai 25%

Metabolisme: Hati (sistem enzim mikrosomal); konjugasi (asam glukuronat / sulfat)

Metabolit: N-asetil-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI; lanjut dimetabolisme melalui konjugasi dengan glutation

eliminasi Half-life: 1,25-3 hr (remaja); 2-5 hr (anak-anak); 4 hr (bayi); 7 hr (neonatus); 2-3 hr (orang dewasa)

Ekskresi: urin (terutama asetaminofen glucuronide dengan acetaminophen sulfat / mercaptate)