Practical research concerns on all the sub-areas relevant to each interoperability issue. Therefore, an E-business Inter- operability Framework should address all the sub-areas of interoperability issues. It also focuses on interoperability issues for which scientific research has proposed a solution that has not yet been applied effectively in the E-business Interoperability Framework. Examples are researches that support process reengineering, rules execution, service chore- ography, social network characteristics infusion, and cloud federation.