OBJECTIVE:To investigate patterns o

OBJECTIVE:

To investigate patterns of osteoarthritis (OA) progression within hand joints and the relationship between hand OA progression and progression of OA at the knee.
METHODS:

Radiographic progression over 6 years, defined as change in osteophytes or joint space narrowing above the smallest detectable change, was assessed on hand and knee radiographs of 236 hand OA patients participating in the Genetics, Arthrosis and Progression (GARP) sibling pair cohort study using OARSI atlas. Clustering of radiographic progression between hand joint groups (DIP, PIP, IP-1 and CMC-1) was assessed using χ(2) test. Symmetry, clustering by row and ray and familial aggregation in sibling pairs were also evaluated. The association between hand OA progression and progression of OA at the knee was assessed using generalised estimating equation analysis.
RESULTS:

There was clustering of OA progression between hand joint groups, the strongest relationship among DIP, PIP and IP-1 joints. Other patterns were symmetry (OR 4.7 (95% CI 3.3 to 6.5)) and clustering by row (OR 2.9 (95% CI 1.9 to 4.6)) but not by ray (OR 1.3 (95% CI 0.7 to 2.4)). There was familial aggregation of hand OA progression. Patients with progression of hand OA had a higher risk for radiographic change at the knee than those without hand OA progression (OR 2.3 (95% CI 1.3 to 4.0)).
CONCLUSIONS:

Progression of hand OA clusters between hand joint groups, especially between IP joints, and within sibling pairs. It is associated with OA change at the knee. These findings contribute to defining hand OA subsets and suggest a role for systemic factors.

Results (Indonesian) 1:

OBJECTIVE:To investigate patterns of osteoarthritis (OA) progression within hand joints and the relationship between hand OA progression and progression of OA at the knee.METHODS:Radiographic progression over 6 years, defined as change in osteophytes or joint space narrowing above the smallest detectable change, was assessed on hand and knee radiographs of 236 hand OA patients participating in the Genetics, Arthrosis and Progression (GARP) sibling pair cohort study using OARSI atlas. Clustering of radiographic progression between hand joint groups (DIP, PIP, IP-1 and CMC-1) was assessed using χ(2) test. Symmetry, clustering by row and ray and familial aggregation in sibling pairs were also evaluated. The association between hand OA progression and progression of OA at the knee was assessed using generalised estimating equation analysis.RESULTS:There was clustering of OA progression between hand joint groups, the strongest relationship among DIP, PIP and IP-1 joints. Other patterns were symmetry (OR 4.7 (95% CI 3.3 to 6.5)) and clustering by row (OR 2.9 (95% CI 1.9 to 4.6)) but not by ray (OR 1.3 (95% CI 0.7 to 2.4)). There was familial aggregation of hand OA progression. Patients with progression of hand OA had a higher risk for radiographic change at the knee than those without hand OA progression (OR 2.3 (95% CI 1.3 to 4.0)).CONCLUSIONS:Perkembangan tangan OA cluster antara tangan bersama kelompok, terutama antara IP sendi, dan dalam saudara kandung. Hal ini terkait dengan perubahan OA di lutut. Temuan ini berkontribusi mendefinisikan subset OA tangan dan menyarankan peran faktor-faktor yang sistemik.

Results (Indonesian) 2:

TUJUAN: Untuk meneliti pola osteoarthritis (OA) perkembangan dalam sendi tangan dan hubungan antara perkembangan OA tangan dan perkembangan OA di lutut. METODE: perkembangan radiografi lebih dari 6 tahun, yang didefinisikan sebagai perubahan osteofit atau ruang sendi menyempit di atas terkecil terdeteksi perubahan, dinilai di tangan dan lutut radiografi dari 236 pasien OA tangan berpartisipasi dalam Genetika, Arthrosis dan Progresi penelitian kohort (GARP) pasangan saudara menggunakan OARSI atlas. Clustering perkembangan radiografi antara kelompok gabungan tangan (DIP, PIP, IP-1 dan CMC-1) dinilai menggunakan χ (2) tes. Simetri, clustering dengan baris dan ray dan agregasi familial dalam pasangan saudara kandung juga dievaluasi. Hubungan antara perkembangan OA tangan dan perkembangan OA pada lutut dinilai menggunakan umum memperkirakan analisis persamaan. HASIL: Ada pengelompokan perkembangan OA antara kelompok gabungan tangan, hubungan terkuat di antara DIP, PIP dan IP-1 sendi. Pola lain yang simetri (OR 4,7 (95% CI 3,3-6,5)) dan clustering dengan baris (OR 2,9 (95% CI 1,9-4,6)) tetapi tidak oleh ray (OR 1,3 (95% CI 0,7-2,4)). Ada agregasi familial perkembangan OA tangan. Pasien dengan perkembangan OA tangan memiliki risiko lebih tinggi untuk perubahan radiografi pada lutut dibandingkan mereka yang tanpa perkembangan OA tangan (OR 2,3 (95% CI 1,3-4,0)). KESIMPULAN: Progresi cluster OA tangan antara kelompok gabungan tangan, terutama antara IP sendi, dan dalam pasangan saudara. Hal ini terkait dengan OA perubahan di lutut. Temuan ini berkontribusi mendefinisikan subset OA tangan dan menunjukkan peran faktor sistemik.