Relocation is a job requirement, so you need to consider the kind of lifestyle your job will dictate. Your routine and life commitments will constantly be interrupted by irregular flight hours, until you gain seniority and the right to pick your flight hours. You should plan to be away from home at least one-third of the time. You can have layovers due to weather and mechanical problems. You may be on call many time, so you need a flexible home life. You need a reliable support system to accommodate any children or pets.