AbstractOBJECTIVE:To examine the as

Abstract
OBJECTIVE:

To examine the association of obesity and osteoarthritis (OA) at various sites in middle aged women and to estimate the magnitude of the weight difference associated with OA.
METHODS:

A co-twin control study was performed within a population based twin study of women aged 48-70. OA was defined radiologically using site specific features and a standard atlas. Twin pairs discordant for OA disease traits were analyzed.
RESULTS:

The mean weight differences (95% CI) within twin pairs discordant for different OA traits were: tibiofemoral osteophytes 3.75 (1.29, 6.21) kg; patellofemoral osteophytes 3.05 (0.96, 5.15) kg; carpometacarpal (CMC) osteophytes 3.06 (0.83, 5.28) kg. There was no significant difference in weight within twin pairs discordant for osteophytes at the distal interphalangeal (DIP) or proximal interphalangeal (PIP) joints or for joint space narrowing at all sites examined except the patellofemoral joint, 4.73 (1.61, 7.84) kg. For each kg increase in weight the increased likelihood of developing different OA traits [OR (95% CI)] was: tibiofemoral osteophytes 1.14 (1.01-1.28), patellofemoral osteophytes 1.32 (1.09-1.59), patellofemoral narrowing 1.15 (1.01-1.30), and CMC osteophytes 1.09 (1.02-1.17).
CONCLUSION:

Obesity is an important risk factor for development of OA at the tibiofemoral and patellofemoral joints of the knee and CMC joints of the hands, with significant increases of 9-13% in risk of OA per kg increase in body weight. This emphasizes the potential importance of even minor weight reduction as a preventive health measure for OA.

Results (Indonesian) 2:

Abstrak
TUJUAN: Untuk mengetahui hubungan obesitas dan osteoarthritis (OA) di berbagai tempat pada wanita paruh baya dan untuk memperkirakan besarnya perbedaan berat badan yang berhubungan dengan OA. METODE: Sebuah studi kontrol co-twin dilakukan dalam suatu populasi berdasarkan studi kembar perempuan berusia 48-70. OA didefinisikan radiologis menggunakan fitur khusus situs dan atlas standar. Pasangan kembar sumbang untuk OA ciri penyakit dianalisis. HASIL: The berarti perbedaan berat (95% CI) dalam pasangan kembar sumbang untuk sifat OA yang berbeda adalah: osteofit tibiofemoral 3,75 (1,29, 6,21) kg; patellofemoral osteofit 3.05 (0.96, 5.15) kg; carpometacarpal (CMC) osteofit 3,06 (0,83, 5,28) kg. Tidak ada perbedaan yang signifikan dalam berat badan dalam pasangan kembar sumbang untuk osteofit pada interphalangeal distal (DIP) atau interphalangeal proksimal (PIP) sendi atau ruang sendi menyempit di semua situs diperiksa kecuali sendi patellofemoral, 4,73 (1,61, 7,84) kg. Untuk setiap kenaikan kg berat badan meningkat kemungkinan mengembangkan sifat OA berbeda [OR (95% CI)] adalah: osteofit tibiofemoral 1,14 (1,01-1,28), patellofemoral osteofit 1,32 (1,09-1,59), patellofemoral penyempitan 1,15 (1,01-1,30) , dan CMC osteofit 1,09 (1,02-1,17). KESIMPULAN: Obesitas merupakan faktor risiko penting untuk pengembangan OA di tibiofemoral dan patellofemoral sendi sendi lutut dan CMC tangan, dengan peningkatan yang signifikan dari 9-13% di risiko OA per kg peningkatan berat badan. Ini menekankan pentingnya potensi bahkan kecil penurunan berat badan sebagai ukuran kesehatan preventif untuk OA.