OBJECTIVE:To investigate whether ra

OBJECTIVE:

To investigate whether radiographic osteoarthritis (OA) is asymmetric and greater on the right side than on the left side in the hands, hips, and knees.
METHODS:

Participants were 489 individuals with posteroanterior hand radiographs from a family study of nodal OA, 1,715 community-derived individuals who had undergone intravenous urography with views of both hips, and 1,729 community-derived individuals with weight-bearing fully extended tibiofemoral (TF) joint and skyline patellofemoral (PF) joint radiographs. All radiographs were evaluated for global OA grade, osteophytes, and joint space narrowing (JSN). Minimum joint space width (JSW) was measured at the hip and knee. Odds ratios (ORs) for global OA on the right side versus the left side were calculated. Osteophytes and JSN were compared by Wilcoxon's signed rank test, and the JSW was compared by paired t-test.
RESULTS:

Global OA was more prevalent on the right side at the distal interphalangeal joints (OR 1.57; 95% confidence interval 1.22, 2.02) and the TF joint (OR 1.24; 95% confidence interval 1.01, 1.52). Osteophyte scores for the fingers were greater on the right side, but JSN was symmetric. At the hip, there were no right-left differences in osteophytosis or JSN, but the JSW was smaller on the left. At the TF joint, the medial compartment was narrower and the lateral compartment wider on the right side, and osteophyte scores were greater on the right side. At the PF joint, there were no right-left differences in osteophytes, and for lone PF joint OA, there were no differences in JSN or the JSW.
CONCLUSION:

This discordance in symmetry suggests that the relative importance of biomechanical factors in the pathogenesis of OA is site-specific and may be discordant for cartilage and bone.

Results (Indonesian) 2:

TUJUAN: Untuk menyelidiki apakah osteoarthritis radiografi (OA) adalah asimetris dan lebih besar di sisi kanan dari pada sisi kiri di tangan, pinggul, dan lutut. Metode: Peserta 489 orang dengan radiografi tangan posteroanterior dari studi keluarga OA nodal, 1.715 individu masyarakat yang diturunkan yang telah menjalani urografi intravena dengan pemandangan dari kedua pinggul, dan 1.729 individu masyarakat yang diturunkan dengan berat-bantalan sepenuhnya diperpanjang tibiofemoral (TF) sendi dan langit patellofemoral (PF) radiografi sendi. Semua radiografi dievaluasi untuk OA kelas global, osteofit, dan ruang sendi menyempit (JSN). Lebar ruang sendi minimal (JSW) diukur pada pinggul dan lutut. Odds ratio (OR) untuk OA global pada sisi kanan versus sisi kiri dihitung. Osteofit dan JSN dibandingkan dengan signed rank test Wilcoxon, dan JSW dibandingkan dengan paired t-test. Hasil: OA global adalah lebih umum di sisi kanan pada sendi interphalangeal distal (OR 1,57; 95% interval kepercayaan 1,22, 2,02) dan sendi TF (OR 1,24; 95% confidence interval 1,01, 1,52). Skor osteofit untuk jari yang lebih besar di sisi kanan, tapi JSN adalah simetris. Di pinggul, tidak ada perbedaan kanan-kiri di osteofitosis atau JSN, tetapi JSW lebih kecil di sebelah kiri. Pada sendi TF, kompartemen medial adalah sempit dan kompartemen lateral yang lebih luas di sisi kanan, dan skor osteofit yang lebih besar di sisi kanan. Pada PF bersama, tidak ada perbedaan kanan-kiri di osteofit, dan untuk tunggal PF bersama OA, tidak ada perbedaan di JSN atau JSW. KESIMPULAN: kejanggalan ini di simetri menunjukkan bahwa kepentingan relatif dari faktor biomekanik dalam patogenesis OA adalah situs-spesifik dan mungkin sumbang untuk tulang rawan dan tulang.