Results (
Thai) 2:
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Most studies using music in MV patients tended to
show a beneficial effect on clinical physiological parameters
such as pulse and respiratory rate, anxiety and pain as
well as blood pressure [9]. Of note, Conrad et al observed
a reduction of sedative drug consumption in a small cohort
of MV patients listening to an hour of a Mozart's piano
sonata [5]. On a biological standpoint, they also demonstrated
that blood interleukin-6 (IL-6), a cytokine involved
in early inflammatory processes, as well as dehydroepiandrosterone,
an upstream common precursor of steroids,
were decreased whereas growth hormone was increased in
response to listening to this classical music [1,5].
Additional evidence that music listening probably affects
the hypothalamus-pituitary-adrenal (HPA) axis also stems
from the work of Chlan et al who evaluated blood levels of
cortisol and corticotrophin in another small cohort of MV
patients [10].
However, for the time being, (i) only a limited number of
MV-patients have been tested with music listening, (ii) the
impact of music has never been evaluated in a crossover
design where patients are their own controls, (iii) patients
still maintained on mild sedation instead of those with
discontinued sedation; have not been thoroughly studied for
responsiveness, and (iv) several essential short-releasing
biological stress/inflammatory responses have not been
explored. In light of these observations, we postulated that
slow-tempo music listening during MV in ICU patients can
(1) reduce sedative drug consumption and slow down vital
signs in not fully alert patients and (2) damper inflammatory
and HPA axis hormonal release.
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