It had been hoped that the side effects (which can include weight gain) of the newer atypical antipsychotics might be less burdensome than those of the older drugs. The National Institutes of Mental Health's Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, published in 2006, found little difference, however, in effectiveness or side effects between the two groups (see "The lessons of CATIE").
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