VI. Inhibitors of Immune Cell Adhes

VI. Inhibitors of Immune Cell Adhesion:
Efalizumab
Efalizumab (LFA-1 Inhibitor) is a humanized IgG1 mAb targeting the CD11a chain of LFA-1 (lymphocyte function associated antigen).
• Mechanism of action:
Efalizumab binds to LFA-1 and prevents the LFA-1-ICAM (intercellular adhesion molecule) interaction to block T-cell adhesion, trafficking, and activation.

Results (Indonesian) 1:

VI. inhibitor kekebalan sel adhesi: Efalizumab Efalizumab (LFA-1 Inhibitor) adalah humanized IgG1 mAb penargetan rantai CD11a LFA-1 (limfosit fungsi yang dikaitkan antigen). • Mekanisme Aksi: Efalizumab mengikat LFA-1 dan mencegah interaksi (interselular adhesi molekul) LFA-1-ICAM blok sel T adhesi, perdagangan dan aktivasi.