Dihydralazine & Minoxidil•its sulfa

Dihydralazine & Minoxidil
•its sulfate-conjugated metabolite which is dilate arterioles and are used in antihypertensive therapy.
•Mechanism of action of dihydralazine is unclear – combined receptor on arterial endothelium  NO release
•Minoxidil probably
activates K+ channels,
leading to hyperpolarization of
smooth muscle cells
 vasodilatation
ARTERIAL

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To: Indonesian

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Dihydralazine & Minoxidil•its sulfate-conjugated metabolite which is dilate arterioles and are used in antihypertensive therapy.•Mechanism of action of dihydralazine is unclear – combined receptor on arterial endothelium  NO release•Minoxidil probablyactivates K+ channels,leading to hyperpolarization ofsmooth muscle cells vasodilatationARTERIAL

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Dihydralazine & Minoxidil
• metabolit sulfat-terkonjugasi nya yang membesar arteriol dan digunakan dalam terapi antihipertensi.
• Mekanisme kerja dihydralazine jelas - gabungan reseptor pada endotelium arteri  NO rilis
• Minoxidil mungkin
mengaktifkan K + saluran,
yang mengarah ke hiperpolarisasi
sel otot polos
 vasodilatasi
ARTERI

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