When possible it is advisable for cryonics patient in a terminal (pre-deanimation) condition to supplement with antioxidants and other agents to reduce the effects of ischemic and other injuries. Magnesium oxide would be given to prevent low magnesium levels, as often occurs in enterically fed patients and which can worsen brain ischemic injury. Mixed tocopherols means both alpha and gamma forms of Vitamin E, because gamma-tocopherol removes the peroxynitrite radical, whereas alpha-tocopherol does not. Vitamin E and fish oils can reduce clotting, but should not be given for a patient likely to be receiving surgery because bleeding can be increased. Curcumin (curry powder) and melatonin could also be given. Vitamin C should not be used because it can become strongly pro-oxidant in ischemic brain tissue.