Results (
Thai) 2:
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Bell et al. [54,58–60] published findings on the development
of quantitative analytical methods for Raman analysis
of solid dosage forms. In one paper, this research team
reported results on Raman mapping of seized ecstasy tablets
[54]. Raman point mapping was performed on tablet
samples on both microscopic and macroscopic scales to
investigate the effects of sampling size on measurement
error. Micro-Raman mapping was achieved using a Raman
microscope with a motorised x-y translation stage, and
macro-Raman maps were obtained using a Raman spectrometer
with an x–y–z stage. Fig. 5 shows a coarse Raman
map of the peak area of the strongest MDMA band in the
Raman spectra of a seized ecstasy tablet, taken at 785 nm
with a Raman microscope (8 · 8 grid, 10 lm spacing, 50·
objective lens). Although only a small number of grid
points were measured (to decrease time and cost of analysis),
inhomogeneous distribution of tablet components
(MDMA, caffeine and lactose) is evident. It was demonstrated
that acceptably low sampling errors could be
achieved when less than 100 points were sampled, and that
sampling error could be estimated by comparison of subsets
of data in the grid. It was reported that for the
macro-Raman system, grid acquisition time of 1 min for
individual tablets could potentially be realised
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