CYCLOSPORINEChemistryCyclosporine i

CYCLOSPORINE
Chemistry
Cyclosporine is a fungal polypeptide composed of 11 amino acids.
Mechanismofaction:
•ActsbyblockingactivationofTcellsbyinhibitinginterleukin-2production(IL-2).
•DecreasesproliferationanddifferentiationofTcells.
•Cyclosporine binds tocyclophilin(immunophilin) intracellular protein receptors .
•Cyclosporine-immunophilincomplex inhibits calcineurin, a phosphatase necessary for dephosphorylationof transcription factor(NFATc) required for interleukins synthesis (IL-2).
•NFATc(Nuclear Fcatorof Activated Tcells).
•Suppressescell-mediatedimmunity.

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SIKLOSPORINKimiaSiklosporin adalah polipeptida jamur terdiri dari 11 asam amino.Mechanismofaction:•ActsbyblockingactivationofTcellsbyinhibitinginterleukin-2production(Il-2).•DecreasesproliferationanddifferentiationofTcells.•Cyclosporine mengikat reseptor protein intraseluler tocyclophilin(immunophilin).•Cyclosporine-immunophilincomplex menghambat calcineurin, fosfatase yang diperlukan untuk dephosphorylationof factor(NFATc) transkripsi yang diperlukan untuk sintesis interleukins (IL-2).•NFATc (Fcatorof nuklir diaktifkan Tcells).•Suppressescell-mediatedimmunity.

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Siklosporin
Kimia
Siklosporin adalah polipeptida jamur terdiri dari 11 asam amino.
Mechanismofaction:
• ActsbyblockingactivationofTcellsbyinhibitinginterleukin-2production (IL-2).
• DecreasesproliferationanddifferentiationofTcells.
• Siklosporin mengikat tocyclophilin (Immunophilin) reseptor protein intraselular.
• Siklosporin-immunophilincomplex menghambat kalsineurin, fosfatase yang diperlukan untuk dephosphorylationof faktor transkripsi (NFATc) diperlukan untuk sintesis interleukin (IL-2).
• NFATc (Nuclear Fcatorof Activated Tcells).
• Suppressescell-mediatedimmunity.

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Results (Indonesian) 3:[Copy]

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