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OzoneOzone is a highly reactive gas and a major constituent of pho- tochemical smog. Breathing only slightly increased concentra- tions of ozone (60–120 ppb) results in a range of respiratory symptoms in a small proportion (10–20%) of the healthy population.3 Symptoms include decreased lung function, increased airway hyperreactivity, and pulmonary inflamma- tion. Those individuals with pre-existing conditions such as asthma and chronic obstructive pulmonary disease generally experience an exacerbation of their symptoms.Ozone is a relatively insoluble gas. It is very reactive, and uptake is directly related to reactions with substrates present in the lung lining fluid, the first compartment it encounters on entering the lung. Langford et al referred to this mechanism as “reactive absorption”.4 The uptake of ozone is thus related not only to its concentration but also availability of substrates within the lung lining fluid compartment. Following reaction with a target substrate, ozone is consumed, disabling it from transiting the lung lining fluid compartment. Cellular responses to ozone are therefore not the result of direct reac- tion of ozone with cell surface components, but are mediated through a cascade of secondary, free radical derived, ozonati
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