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• Therapeutic uses: Adjuvant therapy with 5-fluorouracil after surgical resection in patients with Duke’s stage C colon cancer, agranulocytosis. • Adverse effects: Flu-like symptoms, allergic manifestation, nausea and muscle pain 4. III. Thalidomide: • Mechanism of action: Thalidomide has been reported to decrease circulating TNF-α in patients with erythema nodosum leprosum, but to increase it in patients who are HIV-seropositive. Alternatively, it has been suggested that the drug affects angiogenesis. • Therapeutic uses: Severe, refractory rheumatoid arthritis 4,15,18. • Adverse effects: Teratogenicity
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