Results (
Thai) 1:
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Blood prolactin decreased after music listening (mean ±
SD): 29.3 ± 3.5 μg/L pre- vs 27.4 ± 3.4 μg/L post-music-
MP3, P = .038) while not affected in the placebo-control
group (28.8 ± 4.1 μg/L pre- vs 28.4 ± 4 μg/L post-sham-
MP3, P = .95) (Fig. 3A). Nonsurvivors further exhibited
enhanced baseline blood prolactin (median [25-75th percentiles]):
27.1 [15-49] vs nonsurvivors 18.4 [10.5-31] (P =
.001). The number of “responding” patients (as defined by a
non-enhanced blood prolactin post-music- or sham-MP3
listening) was 32 with music-MP3 vs 21 with sham-MP3
(over 49 patients each) (P = .04) (Fig. 3B).
Excluding patients treated with corticosteroids from the
analysis neither affected the above results nor the comparisons
relative to blood cortisol, ACTH/cortisol, and prolactin
(data not shown).
Changes in blood leptin and MET-enkephalin with music-
MP3 listening were evaluated in the “cortisol-responsive”
subgroup, since rapid modulations of cortisol or vasopressin
release have been associated with these molecules [15,16].
Average leptin as well as MET-enkephalin levels did not
change with music listening (leptin: 19 ± 4 pre- vs 19.6 ± 4
ng/mL post-music, MET-enkephalin: 251 ± 63 pre- vs 252 ±
68 pg/mL post-music, NS), whereas dynamic individual
increases in MET-enkephalin concentrations were negatively
correlated with respective changes in ACTH (R2 = 0.138,
slope −0.3661 ± 0.1, 95%CI: -0.7014 to −0.031 n = 33) and
cortisol (R2 = 0.1885, slope −0.3346 ± 0.1, 95%CI: -0.589 to
−0.080, n = 33), P = .033 and P = .0116, respectively
(Fig. 4A and B).
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