Serine/threonine-protein kinase tha

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

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Serin/Treonina-protein kinase yang memainkan peran penting dalam kontrol siklus sel eukariotik; terlibat dalam G0-G1 dan G1-S siklus sel transisi. Berinteraksi dengan CCNC/siklin-C selama interphase. Phosphorylates histone H1, ATF1, RB1 dan CABLES1. ATF1 fosforilasi memicu ATF1 transactivation dan transcriptional aktivitas, dan mempromosikan proliferasi sel dan transformasi. CDK3/siklin-C ditengahi RB1 fosforilasi diperlukan untuk transisi G0-G1. Mempromosikan G1-S transisi mungkin dengan berkontribusi aktivasi E2F1, E2F2 dan E2F3 secara RB1-independen.

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kinase serin / treonin-protein yang memainkan peran penting dalam mengendalikan siklus sel eukariotik; terlibat dalam G0-G1 dan G1-S transisi siklus sel. Berinteraksi dengan CCNC / cyclin-C selama interfase. Memfosforilasi histone H1, ATF1, RB1 dan CABLES1. ATF1 fosforilasi memicu ATF1 transactivation dan kegiatan transkripsi, dan mempromosikan proliferasi sel dan transformasi. CDK3 / cyclin-C dimediasi RB1 fosforilasi diperlukan untuk transisi G0-G1. Mempromosikan G1-S transisi mungkin dengan memberikan kontribusi untuk aktivasi E2F1, E2F2 dan E2F3 secara RB1-independen.

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