Magnetic coreeshell Fe3O4@SiO2 nanoparticles as special immobilizing carrier of biomolecules have aroused great interest in current researches because they are biocompatible, easily renewable, and are stable against degradation . The inner iron-oxide core with outer shell of silica not only stabilizes the nanoparticles in solution but also provides sites for surface modification
with various biomedical ligands in biomedical applications